Studies on Eastern Equine Encephalomyelitis I . Histopathology of the Nervous System

The pathology of the nervous system in equine encephalomyelitis has been described for both the Western (1) and the Eastern (2) forms of the disease. Much attention has been paid to the intranuclear inclusion bodies, found in glial and mesodermal cells as well as in neurones. The intense inflammation, together with the necrosis of nerve cells, has been reported. I t is the purpose of this paper to record in detail the neuropathologic features of the disease in the guinea pig, and to describe the histogenesis of the disease process. Only the nervous system findings are reported. Details of visceral pathology, described by Hurst (2), have been confirmed but no new observations added.